Windows has a flaw that you have to restart very frequently, however not all system changes actually require a restart, here’s how to apply registry changes without one.
Registry changes do not require a restart, it is sufficient to simply restart the process explorer.exe.
Step 1: Open the task manager and go to the tab processes, right-click on explorer.exe and click End Process
Step 2: Next, you should click on File and then New Task (Run…)
Step 3: Now enter explorer.exe and you’re good to go
Step 4: The explorer.exe has now been restarted and most registry changes are now applied and do not require a full restart of Windows.
Here is a video explaining step by step how to do this :
Knowing this little trick will save you a lot of time, because you no longer have to do a full restart to apply the registry changes.
Source :windows7themes.net